Search results for "Third generation"

Resistance to third-generation cephalosporins in Escherichia coli in the French community: The times they are a-changin'?

2020

Since the early 2000s, Escherichia coli resistance to third-generation cephalosporins (3GCs) has been increasing in all European countries, mainly due to the spread of extended spectrum β-lactamases (ESBLs). Here we present a retrospective study that combines resistance of E. coli to 3GCs and quinolones with data on antibiotic use in the community in a region of Northeastern France.Since 2012, an observational surveillance of antimicrobial resistance and antibiotic use in the community was conducted: data on antimicrobial resistance in E. coli isolates were collected from 11 private laboratories, and consumption data were collected from the three main healthcare insurances.A significant dec…

Tailoring haemophilia A prophylaxis with BAY 81-8973: A case series

2020

BAY 81-8973 is an unmodified, full-length third generation recombinant factor VIII (rFVIII) which offers a more favorable pharmacokinetic (PK) profile, compared to its predecessor sucrose-formulated rFVIII (rFVIII-FS). We here report on a retrospective case series of nine patients affected by hemophilia A (HA), with variable disease severity, bleeding phenotype and comorbidities, to underline our clinical practice on prophylaxis with a recently introduced standard hall-life recombinant Factor VIII. The current case series highlights how the current clinical management of hemophilia is able to personalize treatment in several specific conditions like concomitant illnesses with thrombotic ris…

The role of second-line tyrosine kinase inhibitor monotherapy in EGFR wild-type advanced non-small-cell lung cancer patients: Findings from a retrosp…

2015

e19030 Background: Second-line treatment for advanced non-small-cell lung cancer (aNSCLC) patients includes monotherapy with a third generation cytotoxic drug (CT) or with the tyrosine kinase inhib...

A comparative assessment of the accuracy of electronic apex locator (Root ZX) in the presence of commonly used irrigating solutions

2013

Objectives: This study aimed to evaluate the accuracy of Root ZX in determining working length in presence of normal saline, 0.2% chlorhexidine and 2.5% of sodium hypochlorite. Material and Methods: Sixty extracted, single rooted, single canal human teeth were used. Teeth were decoronated at CEJ and actual canal length determined. Then working length measurements were obtained with Root ZX in presence of normal saline 0.9%, 0.2% chlorhexidine and 2.5% NaOCl. The working length obtained with Root ZX were compared with actual canal length and subjected to statistical analysis. Results: No statistical significant difference was found between actual canal length and Root ZX measurements in pres…

A disponibilidade léxica dos estudantes de educação secundária de valência

2019

This research focuses on another research conducted in a bilingual educational context between Spanish and Valencian, with secondary school students, as is the case in the city of Valencia. In this context, the influence of the Valencian language is not as strong as in other areas of the Valencian Community, due to the presence of second and third generation speakers from Spanish-speaking contexts. In this way, we aim to check if the modality of schooling, carried out by students at the beginning and end of the secondary stage, between the Teaching Program in Valencian and the Progressive Incorporation Program, has some influence on their vocabulary available in Spanish.

In the literature: March 2016

2016

The way clones resistant to anti-EGFR (Epidermal Growth Factor Receptor) inhibition evolve in non-small cell lung cancer is far from being determined. In an international cooperative effort led by investigators at Johns Hopkins Hospital in Baltimore, the origin of acquired resistance mediated by the EGFRT790M mutation has been further elucidated. That mutation, recognised as gatekeeper and present in about 60% of pretreated cases with anti-EGFRs, could occur either from the selection of previously existing EGFR790M cell clones or by the evolution of originally EGFR790M-negative drug-tolerant cells. In a series of elegant experiments, the authors show that these drug-tolerant cells have a di…

Relativistic international development and its potential for implementing self-determination in Ethiopia: Policy recommendations

This paper is an abstract of policy recommendations based on my presentation to the 2019 Annual Conference of Oromo Studies Association. It is included in the official Proceedings of the Conference. A longer paper was published open access in Archivio Antropologico Mediterraneo, XXII, n. 21 (2), 2019, title: 'The relativistic attitude in development: reflections on the implementation of the Ethiopian multinational Constitution'.

La educación para la promoción de los derechos humanos de la tercera generación

2008

The paper deals with the ways to promote the third generation human rights through education. It underlines the evolutionary dynamism of human rights and the necessity to promote a culture based on their recognition. Solidarity is analysed as the value which specify this generation of rights. Then the author defends the rights to a healthy environment, to peoples’ development, and to peace, as key components of any international political community or local communities aiming to meet the requirements of human dignity. Finally, he proposes some pedagogical practices to help the students to become conscious and responsible citizens, so they have the competence to ask to individuals and groups…

The business elite in Finland: a prosopographical study of family firm executives 1762–2010

2015

This study presents a prosopographical analysis of the Finnish business elite. The longitudinal panel dataset includes 456 members of family firms from 1762–2010 who have received the honorary title of counsellor in Finland. Counsellor biographies have been written by an economic history association network of 130 historians. Most family firms are no longer elite after the third generation of the family business or the second counsellor generation; therefore, the same core families rarely remain part of the economic elite for more than 100 years.

A lab in the field: applications of real-time, in situ metagenomic sequencing

2020

High-throughput metagenomic sequencing is considered one of the main technologies fostering the development of microbial ecology. Widely used second-generation sequencers have enabled the analysis of extremely diverse microbial communities, the discovery of novel gene functions, and the comprehension of the metabolic interconnections established among microbial consortia. However, the high cost of the sequencers and the complexity of library preparation and sequencing protocols still hamper the application of metagenomic sequencing in a vast range of real-life applications. In this context, the emergence of portable, third-generation sequencers is becoming a popular alternative for the rapi…